Small cell lung carcinoma (SCLC) is a high-grade pulmonary neuroendocrine tumor.The transcription factors ASCL1 and NEUROD1 play crucial roles in promoting malignant behavior and survival of human SCLC cell lines.Here, we find that ASCL1 and NEUROD1 identify heterogeneity in SCLC, bind distinct genomic loci, and regulate mostly distinct genes.ASCL1
Abstract Objective: To identify factors that determine the negative perception of the health of the Brazilian elderly, considering sociodemographic conditions, functional limitations and illness, patterns of utilization of health services and oral health condition.Method: A cross-sectional study with data from the National Health Survey (2013), inv
Hutterite colonies are a growing and sustainable element in the cultural landscape of the Canadian Prairies and Northern Toggle Switch Great Plains of the United States.Their increasing numbers do something to offset the disappearance of the smallest service centers on the plains.While the diffusion of these communities has been well documented, th
Simulation of beryllium cracking under action of Magnetic Strip multiple severe surface heatings has been performed using the PEGASUS-3D code and verified by experiments in the JUDITH 1 facility.Analysis of the results has revealed beryllium thermo conductivity degradation under action of repetitive pulsed heat load due to accumulation of the crack
Globalization in trade, the continual expansion of the significant European and world-wide foreign trade networks into the countries of Middle andEastern Nasal Care Europe and the rise in the number of shopping and entertainment centres cause changes in consumer behavior in the Slovak, as well as in theCzechRepublic.Results of the marketing researc